Thyroid: Therapies, Confusion, and Fraud
by Dr. Raymond Peat

Dr. Raymond Peat has his doctorate in biology from the University of Oregon, with specialization in physiology, and has taught at many universities.  His study of thyroid hormones began in 1968.  In this very technical report, Dr. Peat says that Dr. Broda Barnes "summed up the major effects of hypothyroidism on health very neatly when he pointed out that if hypothyroid people don't die young from infectious diseases, such as tuberculosis, they die a little later from cancer or heart disease".  Dr. Peat claims that synthetic thyroxine thyroid drugs have perpetuated "50 years of fraud" by the pharmaceutical industry.  He also claims that "an excess of thyroxine, in a tissue that doesn't convert it rapidly to T3, has an antithyroid action.  This happens in many women who are given thyroxine; as their dose is increased, their symptoms get worse."  Dr. Peat also describes how tests showed that "healthy people who weren't taking any thyroid supplement had higher T3:T4 ratios than the people who took thyroxine", and that "our own thyroid gland releases a high ratio of T3 to T4" which is more consistent with the results from people taking the natural glandular, Armour Thyroid.
 

Special thanks to Dr. Lita Lee, Ph. D, who has done so much research on thyroid problems, and how the thyroid gland is affected by today's modern diet.  The following was inspired by her work.  (Click on her name to be taken to her website)

Thyroid basics

Liz Pavek (c)2001

Take a little shield- or butterfly-shaped piece of tissue about the size of a small oyster and place it right at the base of your throat.  Make it totally essential to life and health, and make it secrete some of the most important hormones your body produces. Make it so that if it is removed or damaged, the results will be devastating to your health, including diabetes, heart disease, cancer, and if left untreated, death.

I just described your thyroid gland. This is the gland that secretes the hormones that control your metabolism, so if it is defective, damaged, or starved for nutrients, it will not secrete what you need to live a normal, active life.  The body uses thyroid hormone and vitamin A to change cholesterol into pregnenolone, progesterone, and DHEA.  These are essential hormones for keeping the body young and active. For humans and higher animals, the thyroid can be very easily damaged by radiation.

As a Utah downwinder, I remember receiving iodine tablets all through grade school during the Fifties. Today, I have chronic and systemic disorders that can conceivably be traced to a radiation-damaged thyroid gland. Chronic fatigue and fibromyalgia are just two of the possible radiation/thyroid disorders. Hypoglycemia is another, as well as edema (fluid swelling) and inflammation.  These are all symptoms of a damaged thyroid gland which is not secreting at optimum levels.

Some more of the things that affect and cripple the thyroid include fluoride in water, foods, and toothpastes.  It damages more than 100 kinds of enzymes in the body, which can lead to bone disease, cancer, premature aging, and seizures.  Synthetic hormones (like Premarin® and birth control pills, for example)  also disturb thyroid function.  Unfortunately, these are often found in commercial meat, dairy products, poultry, and eggs.

Unsaturated fats, which are prevalent in the American diet today, exact an even greater toll on thyroid function. Unsaturated fats are those fats which are liquid at room temperature, and include all the seed oils, like borage, evening primrose, flax, etc., as well as fish oils, and corn, safflower, and soybean oil.  Processing of the oils has no effect one way or the other where the thyroid gland is concerned, although it does have an overall effect on the body, as refined/hydrogenated oils introduce free radicals into the body.  But all of the polyunsaturated oils cripple the thyroid to a greater or lesser degree, and prevent the secretion of the essential hormones of metabolism.  

All soy products contain estrogen-type substances that act against the thyroid. They are called "phytoestrogens" and they cause serious inhibition of thyroid hormones.  Too much iodine in the diet is another source of trouble with the thyroid.  Dough conditioners in commercial breads are usually heavy with forms of iodine, and common iodized table salt is also a major contributor to the overdosing on iodine. Even beta-carotene and PABA, common nutrients and vitamins, can exert a negative effect on the thyroid gland.  Mercury in amalgam dental fillings is extremely toxic, and further inhibits the thyroid.  Even endurance running long distances can depress the effectiveness of the thyroid hormones.

Symptoms of hypothyroidism include low body temperature, depression, allergies, frequent colds and flu; fatigue, insomnia, fibromyalgia, weight problems, migraines in cycles, seizures around the time of ovulation and menstruation, goiter, high blood pressure (and low blood pressure, too), persistent weight gain as well as underweight, ADHD, PMS, bronchitis and asthma, fibrocystic breasts and ovarian cysts, mood swings, fibroids of the uterus, infertility, miscarriage near the 10th week, menstrual problems; aging problems, such as heart disease, gall bladder problems, tumors, cancer, diabetes, senility. 

When the blood cholesterol rises in a patient's body, it is because there is insufficient thyroid hormone present to convert it to bile salts and hormones like progesterone, pregnenolone, and DHEA.  These hormones are essential for prevention of obesity, heart disease, cancer, tumors, memory loss, and other aging-related disorders.

The liver uses glucose to convert thyroxine (T4) to its active form, triiodothyronine, or liothyronine (T3).  If there is not sufficient T3 present in the body, the mitochondria in the cells do not work.  The electron transport chain which culminates in the production of oxygen is affected if sufficient T3 is not present.  In the absence of sufficient amounts of T3, glucose is burned inefficiently into a form of lactic acid instead of complete combustion to carbon dioxide.  In this event, the body gets insufficient energy from the glucose of the diet. 

 If the liver uses up its store of glycogen, the process of converting T4 to T3 comes to a stop.  Hypoglycemia is a result of this, and hypoglycemia overstimulates  adrenalin in order to keep the body functioning in the event of insufficient glucose in the cells.  In hypothyroid patients, the excretion of 30 to 40 times the normal amounts of adrenalin metabolites is common.  In the presence of low blood sugar, adrenalin attempts to mobilize glycogen, then stored fat.  Then progesterone is converted to cortisol in the adrenal medulla. 

A pituitary hormone (ACTH) is secreted, which responds to adrenalin.  Cortisol stimulates the production of blood sugar by the catabolism of protein in order to increase blood sugar (glucose).  Cortisol decreases adrenalin and causes a slow pulse, a condition common in those with underactive thyroid glands.  If the adrenal cortex is forced to over-secrete for too long, it begins to fail.  It cannot produce enough cortisol to control the blood sugar, and the adrenalin rises.  This causes what is called "adrenalin dominance." 

Sometimes, rarely, a very high pulse (often as high as 120-150) is found, in spite of the patient having a hypothyroid condition.  Correction with proper supplementation can bring this pulse rate back down to the normal range, around 85 beats per minute.  

Cortisol is produced in the hypoglycemic individual in order to keep the blood sugar up, but cortisol inhibits the thyroid, which makes problems worse for the sufferer.  Hormone balancing therapy is the only way to rectify this problem in hypothyroditic individuals.  This would include supplementation of thyroid hormone replacement, as well as replacement of progesterone, and adrenal support.  Excess cortisol leads to hot flashes, night sweats, diabetes, bone loss, and glaucoma.

   "Adrenalin and its synthetic drug mimics, such as those used in asthma, are toxic when used or produced continuously in response to the stress of hypothyroidism and endurance exercise.  Excess adrenalin is cardiotoxic because it damages heart mitochondria (Voino-Yasenetskaya; Meerson).  Peat suggests that this is due to abnormally rapid mobilization and oxidation of unsaturated fatty acids leading to peroxidation, aggravated by inadequate antioxidant protection.  Barnes has many years of research on the cardioprotective effects of thyroid therapy on his diabetic patients, who normally have an increased risk to heart disease.  This led him to conclude that the cardiovascular complications of diabetes are due to low thyroid function, not insulin."  --  Lita Lee, "Hypothyroidism, a Modern Epidemic," Oct. 2000.

Cancer is also a risk with hypothyroidism in both sexes, because so many types of cancer are estrogen-responsive, and hypothyroidism allows estrogen to become dominant, by not allowing the secretion of progesterone, pregnenolone, or DHEA.

Hyperactive adrenals can stimulate a high-blood pressure response in susceptible individuals.  But if the adrenals become exhausted, the blood pressure will fall quickly to below-normal levels. Thyroid hormones increase metabolism and stimulate circulation, which will lead to lower NORMAL blood pressure.

WHAT SHOULD I EAT?

  • A diet rich in animal protein and animal-source fatty acids.  Animal protein is essential for stimulation of thyroid hormone, as well as helping the liver to convert it to active, usable form.  Eat some form of animal protein at every meal.
  • Fats and oils rich in saturated fatty acids, like butter, coconut oil, palm oil, lard, and tallow.  Leave the fats on your meat cuts.  If they are trimmed lean, add butter or coconut oil (this adds a delicious taste, as well as nutritious fatty acids.).

WHAT SHOULD I AVOID?

  • A vegetarian diet.  Vegetable protein, such as that found in soy products, will not only not stimulate the production of thyroid hormone, but soy contains compounds that actually suppress the action of the thyroid gland.
  • All soy products, for the reasons mentioned above.  Soy is found hidden in many commercial foods as hydrolized vegetable protein, MSG, or soy protein isolate.  Read ingredient panels carefully.
  • Raw vegetables of the cabbage family, like cauliflower, broccoli, cabbage, Brussels sprouts, etc.  These foods must be cooked in order to destroy the thyroid inhibitors.
  • All substances that stimulate or produce estrogens.  This includes especially products like birth control pills, Premarin® or other conjugated estrogens; herbs like black cohosh, sage, pennyroyal, licorice, and ALL unsaturated oils.
  • Too much iodine.  This is generally not too much of a problem, but it is conceivable that an individual could take an iodine supplement, and add too much iodized salt to his food.  Iodine is present in many vegetables, and small amounts are found in multivitamin supplements, sufficient to provide what the thyroid needs for health.
  • PABA.  A sunscreen and member of the B-complex family of vitamins.  Avoid vitamin supplements with large amounts. It is extremely antagonistic to the thyroid.
  • Beta-carotene, because it is also thyroid-antagonistic.  Do not drink carrot juice, for instance, because of the high concentration of thyroid inhibitors.
  • Avoid pesticides.  They are all very estrogenic, which means that by themselves they are severely thyroid-inhibiting.  
  • Avoid fluoride in any form.  Fluoride is very antagonistic to the essential enzymes in the body that produce metabolic activity.  Fluoride can cause cancer, seizures, bone disease, and early aging.
  • Avoid mercury in all forms.  Amalgam fillings are the highest single source of mercury poisoning in humans.  Find a dentist who will remove the amalgam fillings and replace them with composite or epoxy fillings.

THYROID AND MULTIPLE SCLEROSIS

Generally, MS can be traced to environmental poisoning, such as radiation or heavy metal exposure, such as lead or mercury.  Here is how one expert describes the process: "Cells called "oligodendrocytes" are responsible for myelinating nerve fibers and are steroid-forming cells.  Specifically, they produce pregnenolone.  In MS, these oligodendrocytes appear to stop functioning.  The clustering of oligodendrocytes around deteriorating nerve cells may be an attempt to provide pregnenolone to the injured cells." --- Ray Peat, Ph. D.

Sometimes MS patients suffer from undiagnosed hypothyroidism, especially if they aren't overweight or seriously disabled.  MS symptoms sometimes disappear under proper thyroid therapy.

THYROID AND ESTROGEN

Many of the problems that afflict women can be traced by careful researchers to a lower-than-normal thyroid function.  Even if the estrogen level is normal, the woman still suffers most of the known "female disorders."  Unsuspecting doctors often prescribe estrogen therapy for these problems, and do nothing but make the woman sicker by exacerbating her original symptoms.  Simply put, estrogen inhibits thyroid production.  Progesterone, on the other hand, is a thyroid stimulant.  Progesterone is made by the body from cholesterol if there is adequate thyroid hormone present and if there is sufficient intake of vitamin A.  

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